GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2028299 | 1 | rs4932143 | chr15:90372067 | AP3S2 | chr15:90373832-90456222:- | -0.73 | -18.17 | 1.74E-56 | Type 2 diabetes |
| THCA | cis | rs2028299 | 1 | rs4932143 | chr15:90372067 | C15orf38 | chr15:90443832-90456222:- | 0.35 | 7.46 | 4.08E-13 | Type 2 diabetes |
| THCA | cis | rs2028299 | 1 | rs4932148 | chr15:90394356 | AP3S2 | chr15:90373832-90456222:- | -0.78 | -19.51 | 8.88E-63 | Type 2 diabetes |
| THCA | cis | rs2028299 | 1 | rs4932148 | chr15:90394356 | C15orf38 | chr15:90443832-90456222:- | 0.36 | 7.58 | 1.77E-13 | Type 2 diabetes |
| THCA | cis | rs4935969 | 1 | rs4935969 | chr11:126296589 | FOXRED1 | chr11:126139055-126148026:+ | -0.14 | -3.58 | 0.000374 | Hair color |
| THCA | cis | rs4936323 | 1 | rs4936323 | chr11:115091119 | CADM1 | chr11:115039953-115375241:- | -0.14 | -3.35 | 0.000878 | Response to cytadine analogues (cytosine arabinoside) |
| THCA | cis | rs6421571 | 1 | rs4936444 | chr11:118743338 | TREH | chr11:118528942-118550381:- | 0.22 | 3.66 | 0.000275 | Primary biliary cirrhosis |
| THCA | cis | rs17122021 | 1 | rs4938493 | chr11:118144804 | AMICA1 | chr11:118064442-118095809:- | 0.09 | 4.11 | 4.72E-5 | Pain |
| THCA | cis | rs17122021 | 1 | rs4938493 | chr11:118144804 | MPZL2 | chr11:118124135-118135009:- | 0.23 | 7.78 | 4.48E-14 | Pain |
| THCA | cis | rs17122021 | 1 | rs4938493 | chr11:118144804 | TREH | chr11:118528942-118550381:- | -0.17 | -3.38 | 0.000783 | Pain |
| THCA | cis | rs4938642 | 1 | rs4938637 | chr11:119075323 | CBL | chr11:119076990-119178858:+ | -0.22 | -4.37 | 1.55E-5 | Platelet count |
| THCA | cis | rs4938642 | 1 | rs4938642 | chr11:119099906 | CBL | chr11:119076990-119178858:+ | -0.23 | -4.54 | 6.98E-6 | Platelet count |
| THCA | cis | rs4938642 | 1 | rs4938644 | chr11:119153359 | CBL | chr11:119076990-119178858:+ | -0.21 | -4.02 | 6.71E-5 | Platelet count |
| THCA | cis | rs983392 | 1 | rs4939311 | chr11:59877967 | MS4A14 | chr11:60145958-60185226:+ | 0.18 | 4.67 | 3.95E-6 | Alzheimer's disease (late onset) |
| THCA | cis | rs983392 | 1 | rs4939312 | chr11:59900106 | MS4A14 | chr11:60145958-60185226:+ | -0.17 | -4.41 | 1.3E-5 | Alzheimer's disease (late onset) |